MS-172: Paxton Family Papers

This set of papers presents a variety of notes and correspondences between members of the family and friends. The bulk of the letters date 1895 and come from Elizabeth D. Paxton and Margaretta Paxton to their mother, Caroline Sophia Denny Paxton, while touring Europe. There are letters from James Dunlop and Harmar Denny to their mother, as well as condolence letters for Mr. and Mrs. William M. Paxton upon the death of Harmar Denny in 1896. This collection may prove useful for a researcher conducting a study of the Paxton family, or one interested in the travels of Americans in Europe at the end of the 19th century. This collection does not contain information relevant to William Miller Paxton’s time at Gettysburg or his career. Special Collections and College Archives Finding Aids are discovery tools used to describe and provide access to our holdings. Finding aids include historical and biographical information about each collection in addition to inventories of their content. More information about our collections can be found on our website http://www.gettysburg.edu/special_collections/collections/.https://cupola.gettysburg.edu/findingaidsall/1143/thumbnail.jp

Field and Factory: Chinese Revolutionary Posters

The images on display for Field and Factory, political propaganda used by the Communist Party of China during the 1950s, 60s, and 70s, construct a fictitious world. In perceiving these kinds of illustrations, the audience is asked either to visualize the society in its ideal form or unify in opposition to a national enemy. In the first half of the twentieth century, before the possibilities of the television advertisement were fully realized, posters were one of the most popular forms of propaganda: cheap to produce in mass quantities and simple enough to hang in any public building. The art form’s bold aesthetics encouraged mass mobilization during intense periods of war and political upheaval. The posters in this exhibition represent a myriad of political agendas promoted by the Communist Party of China during its early development after the formation of the People’s Republic of China in 1949. Posters were viewed by all citizens in both the private and public sphere; by abolishing other varieties of personal expression, the Communist Party sought control of its population. Whether the posters were sought after as decoration in the home or transmitters of political policy, they became, by default, the most popular form of imagery in China during that time. By glorifying certain aspects of Chinese life, these images help to shape the elements of national identity for a newly founded modern China. [excerpt]https://cupola.gettysburg.edu/artcatalogs/1012/thumbnail.jp

An Impossible Utopia: People’s Art and the Cultural Revolution

The Great Proletarian Cultural Revolution period of the People’s Republic of China (1966-1976) was crucial in the creation of modern-day China. The material culture of that period mirrors the turbulent political activity of students and the directives of the Communist Party’s central leadership during the height of the Mao Zedong personality cult. The commercial manufacture of posters, often the sole decoration available for the public and private spheres, offers strong examples of the design style of this time. The posters are not only indicative of the propagandistic fervor of production, but the aesthetic changes initiated in the visual and performing arts during the period as the state consciously manipulated style in an effort to create a “people’s” art and envision a Marxist utopia. This paper suggests that a comprehension of folk arts and popular culture is essential for understanding the visual language of this specific geographic and political space. A new perspective on the reconciliation of reality and ideology during the Cultural Revolution is gained through an analysis of popular form and content, and reveals not only the basis of a modern mass culture, but the unprecedented unification of high and low art forms

Exploring the Educational Value of the Undergraduate Teaching Apprentice (UTA) Experience

Employing graduate students as teaching assistants (GTAs) is a common practice in universities across the United States. Using undergraduate students as teaching assistants/apprentices (UTAs), however, is not only less common but also often sparks debate among various stakeholder groups (e.g., teachers, administrators, community members). Moreover, relatively little empirical research has been published to support arguments on either side of the issue. The present study extends research by providing evidence to support the educational value of employing UTAs as teaching apprentices. More specifically, researchers conducted a grounded theory qualitative analysis of free-write essay responses collected from 33 UTAs throughout the course of their first semester serving as teaching apprentices. Three learning outcome themes emerged from the analysis: teaching as challenging, teaching as rewarding, and teaching as transformational. Conclusions support the educational value of UTAs as a transformative learning experience

Art+Politics

For the exhibition Art + Politics, students worked closely with the holdings of Gettysburg College\u27s Special Collections and College Archives to curate an exhibition in Schmucker Art Gallery that engages with issues of public policy, activism, war, propaganda, and other critical socio-political themes. Each of the students worked diligently to contextualize the objects historically, politically, and art-historically. The art and artifacts presented in this exhibition reveal how various political events and social issues have been interpreted through various visual and printed materials, including posters, pins, illustrations, song sheets, as well as a Chinese shoe for bound feet. The students\u27 essays that follow demonstrate careful research and thoughtful reflection on the American Civil War, nineteenth-century politics, the First and Second World Wars, World\u27s Fairs, Dwight D. Eisenhower\u27s campaign, Vietnam-War era protests, and the Cultural Revolution in China. [excerpt]https://cupola.gettysburg.edu/artcatalogs/1009/thumbnail.jp

Embryo movement is more frequent in avian brood parasites than birds with parental reproductive strategies.

Funder: Tanzanian Commission for Science and TechnologyFunder: Tanzania Wildlife Research InstituteFunder: NERCFunder: National Science FoundationFunder: Ministry of EducationFunder: German Academic Exchange ServiceFunder: University of Cape TownFunder: Max-Planck-GesellschaftMovement of the embryo is essential for musculoskeletal development in vertebrates, yet little is known about whether, and why, species vary. Avian brood parasites exhibit feats of strength in early life as adaptations to exploit the hosts that rear them. We hypothesized that an increase in embryonic movement could allow brood parasites to develop the required musculature for these demands. We measured embryo movement across incubation for multiple brood-parasitic and non-parasitic bird species. Using a phylogenetically controlled analysis, we found that brood parasites exhibited significantly increased muscular movement during incubation compared to non-parasites. This suggests that increased embryo movement may facilitate the development of the stronger musculoskeletal system required for the demanding tasks undertaken by young brood parasites

HIV policy: the path forward--a joint position paper of the HIV Medicine Association of the Infectious Diseases Society of America and the American College of Physicians.

Executive Summary The American College of Physicians (ACP) and the Infectious Diseases Society of America (IDSA) have jointly published 3 policy statements on AIDS, the first in 1986 [1], the second in 1988 [2], and the third in 1994 [3]. In 2001, the IDSA created the HIV Medicine Association (HIVMA), and this updated policy paper is a collaboration between the ACP and the HIVMA of the IDSA. Since the last statement, many new developments call for the need to reexamine and update our policies relating to HIV infection. First, there have been major advances in treatment for HIV infection that have transformed HIV/AIDS from a terminal illness to a chronic disease for many of those who have access to potent therapies and expert medical care [4]. Second, there has been a profound expansion and intensification of the global HIV pandemic, particularly in sub-Saharan Africa, coupled with significant US leadership and resources aimed at providing prevention and care services to affected populations in developing countries. Third, the concerns that were prevalent in the mid-1990s regarding the possibility of HIV transmission in health care settings have ultimately proven to be unfounded as the result of the adoption of universal precautions in those settings. In this article, we emphasize the public health and clinical imperatives for earlier identification of persons with HIV infection; the urgent need to expand access to state-of-the-art HIV care and treatment for infected individuals; the need for access to comprehensive prevention and education for those living with and those at risk for HIV infection; and the need for stronger national leadership to respond to the HIV epidemic in the United States and in the developing world. In December 2008, the ACP and HIVMA released a guidance statement on screening for HIV infection in health care settings that recommended that clinicians adopt routine screening for HIV infection and encourage patients to be tested. Also included in the guidance statement is a recommendation that clinicians determine the need for additional screening on an individual basis

An expansive human regulatory lexicon encoded in transcription factor footprints.

Regulatory factor binding to genomic DNA protects the underlying sequence from cleavage by DNase I, leaving nucleotide-resolution footprints. Using genomic DNase I footprinting across 41 diverse cell and tissue types, we detected 45 million transcription factor occupancy events within regulatory regions, representing differential binding to 8.4 million distinct short sequence elements. Here we show that this small genomic sequence compartment, roughly twice the size of the exome, encodes an expansive repertoire of conserved recognition sequences for DNA-binding proteins that nearly doubles the size of the human cis-regulatory lexicon. We find that genetic variants affecting allelic chromatin states are concentrated in footprints, and that these elements are preferentially sheltered from DNA methylation. High-resolution DNase I cleavage patterns mirror nucleotide-level evolutionary conservation and track the crystallographic topography of protein-DNA interfaces, indicating that transcription factor structure has been evolutionarily imprinted on the human genome sequence. We identify a stereotyped 50-base-pair footprint that precisely defines the site of transcript origination within thousands of human promoters. Finally, we describe a large collection of novel regulatory factor recognition motifs that are highly conserved in both sequence and function, and exhibit cell-selective occupancy patterns that closely parallel major regulators of development, differentiation and pluripotency

The accessible chromatin landscape of the human genome

DNaseI hypersensitive sites (DHSs) are markers of regulatory DNA and have underpinned the discovery of all classes of cis-regulatory elements including enhancers, promoters, insulators, silencers, and locus control regions. Here we present the first extensive map of human DHSs identified through genome-wide profiling in 125 diverse cell and tissue types. We identify ~2.9 million DHSs that encompass virtually all known experimentally-validated cis-regulatory sequences and expose a vast trove of novel elements, most with highly cell-selective regulation. Annotating these elements using ENCODE data reveals novel relationships between chromatin accessibility, transcription, DNA methylation, and regulatory factor occupancy patterns. We connect ~580,000 distal DHSs with their target promoters, revealing systematic pairing of different classes of distal DHSs and specific promoter types. Patterning of chromatin accessibility at many regulatory regions is choreographed with dozens to hundreds of co-activated elements, and the trans-cellular DNaseI sensitivity pattern at a given region can predict cell type-specific functional behaviors. The DHS landscape shows signatures of recent functional evolutionary constraint. However, the DHS compartment in pluripotent and immortalized cells exhibits higher mutation rates than that in highly differentiated cells, exposing an unexpected link between chromatin accessibility, proliferative potential and patterns of human variation